{ "_id": "6a156701acfb0bcc41d61f10", "Package": "HDStIM", "Type": "Package", "Title": "High Dimensional Stimulation Immune Mapping ('HDStIM')", "Version": "1.0.0", "Authors@R": "c(person(given = \"Rohit\",\nfamily = \"Farmer\",\nrole = c(\"aut\", \"cre\"),\nemail = \"rohit.farmer@gmail.com\",\ncomment = c(ORCID = \"0000-0003-4197-3047\")),\nperson(given = \"Richard\",\nfamily = \"Apps\",\nrole = \"aut\",\nemail = \"richard.apps@nih.gov\",\ncomment = c(ORCID = \"0000-0001-5140-0141\")),\nperson(given = \"John\",\nfamily = \"Tsang\",\nrole = c(\"aut\",\"pdr\"),\nemail = \"john.tsang@nih.gov\",\ncomment = c(ORCID = \"0000-0003-3186-3047\")))", "Description": "A method for identifying responses to experimental\nstimulation in mass or flow cytometry that uses high\ndimensional analysis of measured parameters and can be\nperformed with an end-to-end unsupervised approach. In the\ncontext of in vitro stimulation assays where high-parameter\ncytometry was used to monitor intracellular response markers,\nusing cell populations annotated either through automated\nclustering or manual gating for a combined set of stimulated\nand unstimulated samples, 'HDStIM' labels cells as responding\nor non-responding. The package also provides auxiliary\nfunctions to rank intracellular markers based on their\ncontribution to identifying responses and generating diagnostic\nplots.", "License": "CC0 | file LICENSE", "Encoding": "UTF-8", "LazyData": "true", "LazyDataCompression": "xz", "RoxygenNote": "7.2.3", "URL": "https://github.com/niaid/HDStIM, https://niaid.github.io/HDStIM/", "BugReports": "https://github.com/niaid/HDStIM/issues", "biocViews": "ComplexHeatmap", "VignetteBuilder": "knitr, rmarkdown", "Language": "en-US", "Config/pak/sysreqs": "libicu-dev libpng-dev perl libclang-dev", "Repository": "https://niaid.r-universe.dev", "Date/Publication": "2023-10-05 20:19:14 UTC", "RemoteUrl": "https://github.com/niaid/hdstim", "RemoteRef": "HEAD", "RemoteSha": "b42e3d83871fe6077362e5a36ab065360a25184e", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-26 09:19:57 UTC", "User": "root" }, "Author": "Rohit Farmer [aut, cre] (ORCID:\n),\nRichard Apps [aut] (ORCID: ),\nJohn Tsang [aut, pdr] 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